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Article

Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity.

Cancer research - 1 May 2005

Sotillo Rocío, Renner Oliver, Dubus Pierre, Ruiz-Cabello Jesús, Martín-Caballero Juan, Barbacid Mariano, Carnero Amancio, Malumbres Marcos

Abstract excerpt

Deregulation of the G1-S transition of the cell cycle is a common feature of human cancer. Tumor-associated alterations in this process frequently affect cyclin-dependent kinases (Cdk), their regulators (cyclins, INK4 inhibitors, or p27Kip1), and their substrates (retinoblastoma protein). Although these proteins are generally thought to act in a linear pathway, mutations in different components frequently...

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PMID: 15867383
DOI: 10.1158/0008-5472.CAN-04-4195

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Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity.PMID 15867383Read ↗

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