Article
Multimerization of the adenovirus DNA-binding protein is the driving force for ATP-independent DNA unwinding during strand displacement synthesis.
The EMBO journal - 17 Mar 1997
Dekker J, Kanellopoulos P N, Loonstra A K, van Oosterhout J A, Leonard K, Tucker P A, van der Vliet P C
Abstract excerpt
In contrast to other replication systems, adenovirus DNA replication does not require a DNA helicase to unwind the double-stranded template. Elongation is dependent on the adenovirus DNA-binding protein (DBP) which has helix-destabilizing properties. DBP binds cooperatively to single-stranded DNA...
Topics
- Adenosine Triphosphate
- Adenoviridae
- Animals
- Baculoviridae
- Base Sequence
- Cell Line
- DNA Primers
- DNA Replication
- DNA, Single-Stranded
- DNA, Viral
- DNA-Binding Proteins
- Models, Molecular
- Molecular Structure
- Mutation
- Nucleic Acid Conformation