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Article

Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers.

Arthritis and rheumatism - 1 Mar 2008

Nistala Kiran, Moncrieffe Halima, Newton Katy R, Varsani Hemlata, Hunter Patricia, Wedderburn Lucy R

Abstract excerpt

OBJECTIVE: To identify interleukin-17 (IL-17)-producing T cells from patients with juvenile idiopathic arthritis (JIA), and investigate their cytokine production, migratory capacity, and relationship to Treg cells at sites of inflammation, as well as to test the hypothesis that IL-17+ T cell numbers correlate with clinical phenotype in childhood arthritis. METHODS: Flow cytometry was used to analyze the...

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Identifiers

PMID: 18311821
DOI: 10.1002/art.23291
PMCID: PMC2675006

Genes

CCL20
CCR4
CCR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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