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Article

The −590CC Genotype in the IL4 Gene as a Strong Predictive Factor for the Development of Hypothyroidism in Hashimoto Disease

29 Feb 2008

Abstract excerpt

The severity of Hashimoto disease (HD) varies among patients and is difficult to predict when the disease is in the subclinical state and diagnosed by the presence of thyroid-specific autoantibody. Likewise, the intractability of Graves disease (GD) is difficult to predict. Autoimmune thyroid destruction that underlies both diseases is strongly determined by T-cell cytotoxicity, which is activated by interferon...

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PMID: 18310157
DOI: 10.1373/clinchem.2007.099739

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