Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-thyrotropin receptor antibody.

Clinical and experimental immunology - 1 May 2009

Inoue N, Watanabe M, Nanba T, Wada M, Akamizu T, Iwatani Y

Abstract excerpt

The severity of Hashimoto's disease (HD) and intractability of Graves' disease (GD) varies among patients. Severity of HD is associated with the functional +874A/T polymorphism for interferon-gamma, an inflammatory cytokine. To clarify the association between functional polymorphisms in two other inflammatory cytokine genes [tumour necrosis factor (TNF)-alpha and interleukin (IL)-2] and the severity of autoimmune...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Graves Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hashimoto Disease

Share to Interleukin-2

Share to Iodide Peroxidase

Share to Receptors, Thyrotropin

Share to Statistics, Nonparametric

Share to Thyroglobulin

Source

Open in PubMed Open full text

Identifiers

PMID: 19250279
DOI: 10.1111/j.1365-2249.2009.03884.x
PMCID: PMC2759465

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-thyrotropin receptor antibody.PMID 19250279Read ↗

Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune thyroid disease.Semantic proximity Read ↗

Association of functional GITR gene polymorphisms related to expression of glucocorticoid-induced tumour necrosis factor-receptor (GITR) molecules with prognosis of autoimmune thyroid disease.Semantic proximity Read ↗

Association of TNF-alpha, TNF-beta, IFN-gamma and IL-1Ra gene polymorphisms with Graves' disease in the Thai population.Semantic proximity Read ↗

Association of the -31C/T functional polymorphism in the interleukin-1beta gene with the intractability of Graves' disease and the proportion of T helper type 17 cells.Semantic proximity Read ↗

Methylation levels of the TNFA gene are different between Graves' and Hashimoto's diseases and influenced by the TNFA polymorphism.Semantic proximity Read ↗

The −590CC Genotype in the IL4 Gene as a Strong Predictive Factor for the Development of Hypothyroidism in Hashimoto DiseaseSemantic proximity Read ↗

Plasma VEGF-related polymorphisms are implied in autoimmune thyroid diseases.Semantic proximity Read ↗

Association of cytokine gene polymorphisms (IL6, IL10, TNF-α, TGF-β and IFN-γ) and Graves' disease in Turkish population.Semantic proximity Read ↗

The combination of ınterleukin-10 -1082 and tumor necrosis factor α -308 or ınterleukin-6 -174 genes polymorphisms suggests an association with susceptibility to Hashimoto's thyroiditis.Semantic proximity Read ↗

General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD.Semantic proximity Read ↗

Association of functional polymorphisms in promoter regions of IL5, IL6 and IL13 genes with development and prognosis of autoimmune thyroid diseases.Semantic proximity Read ↗

TNF gene polymorphisms in Graves' disease: TNF-308 A/G meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.