Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between the severity of Hashimoto's disease and the functional +874A/T polymorphism in the interferon-gamma gene.

Endocrine journal - 1 Aug 2006

Ito Chisato, Watanabe Mikio, Okuda Noriko, Watanabe Chikami, Iwatani Yoshinori

Abstract excerpt

CD8+ CD25+-activated cytotoxic T cells and anti-thyroglobulin antibodies (TgAb) are independently involved in the severity of Hashimoto's disease (HD). Interferon gamma (IFN-gamma) activates cytotoxic T cells. To evaluate the hypothesis that the functional +874A/T polymorphism in the gene encoding IFN-gamma is associated with the severity of HD, we examined the frequencies of this polymorphism in 34 HD patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Electrophoresis, Agar Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Graves Disease

Share to Hashimoto Disease

Share to Statistics, Nonparametric

Share to Thyrotropin

Share to Thyroxine

Share to Triiodothyronine

Source

Identifiers

PMID: 16820703
DOI: 10.1507/endocrj.k06-015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between the severity of Hashimoto's disease and the functional +874A/T polymorphism in the interferon-gamma gene.PMID 16820703Read ↗

The −590CC Genotype in the IL4 Gene as a Strong Predictive Factor for the Development of Hypothyroidism in Hashimoto DiseaseSemantic proximity Read ↗

IL-10 -592A/C polymorphism is associated with severity of Hashimoto's disease.Semantic proximity Read ↗

A differential association of interferon-gamma high-producing allele T and low-producing allele A (+874 A/T) with Hashimoto's thyroiditis and Graves' disease.Semantic proximity Read ↗

The +869T/C polymorphism in the transforming growth factor-beta1 gene is associated with the severity and intractability of autoimmune thyroid disease.Semantic proximity Read ↗

Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-thyrotropin receptor antibody.Semantic proximity Read ↗

The IL15 +96522 A>T functional polymorphism is related to the differentiation of Th17 cells and the severity of Hashimoto's disease.Semantic proximity Read ↗

Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease.Semantic proximity Read ↗

Association of functional polymorphisms related to the transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases.Semantic proximity Read ↗

Functional polymorphisms affecting Th1 differentiation are associated with the severity of autoimmune thyroid diseases.Semantic proximity Read ↗

Cytotoxic T-lymphocyte associated antigen 4 polymorphism and Hashimoto's thyroiditis susceptibility: a meta-analysis.Semantic proximity Read ↗

Immunological changes of T helper cells in flow cytometer‑sorted CD4+ T cells from patients with Hashimoto's thyroiditisSemantic proximity Read ↗

Association of functional polymorphisms in promoter regions of IL5, IL6 and IL13 genes with development and prognosis of autoimmune thyroid diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.