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Article

Arg25Pro (c.915G>C) polymorphism of transforming growth factor β1 gene suggests an association with increased risk for Hashimoto's thyroiditis.

International immunopharmacology - 1 Sept 2015

Vural Pervin, Değirmencioğlu Sevgin, Doğru-Abbasoğlu Semra, Baki Merve, Özderya Ayşenur, Karadağ Berrin, Uysal Müjdat

Abstract excerpt

BACKGROUND: The etiopathogenesis of Hashimoto's thyroiditis (HT) - has not been clearly elucidated although the role of chronic inflammation, endothelial dysfunction, and imbalance between pro- and anti-inflammatory cytokines has been established. Transforming growth factor β1 (TGFβ1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, production of autoantibodies and...

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PMID: 26218277
DOI: 10.1016/j.intimp.2015.07.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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