Genetic variants of interleukin-4 gene in autoimmune thyroid diseases: an updated meta-analysis.

doi:10.3109/08916934.2014.962025

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Article

Genetic variants of interleukin-4 gene in autoimmune thyroid diseases: an updated meta-analysis.

Autoimmunity - 1 Mar 2015

Shen Xiaokun, Yan Xingqiang, Xie Bojian, Xu Dong, Wang Kuifeng, Zhu Jiansheng, Li Jichen, Zhang Xiaohua, Cao Feilin

Abstract excerpt

Autoimmune thyroid diseases (AITDs) including Graves' disease (GD) and Hashimoto's thyroiditis (HT) are common autoimmune endocrine disorders. Interleukin-4 (IL-4), a cytokine secreted by T cells, plays a critical role in antigen-specific Th2 responses. The IL-4 gene is highly polymorphic and it has been reported that the polymorphism at -590 (T/C, rs2243250) in the promoter region of IL-4 may contribute to the...

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PMID: 25286078
DOI: 10.3109/08916934.2014.962025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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