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Article

Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.

Diabetes care - 1 Jan 2004

Rudofsky Gottfried, Reismann Peter, Witte Steffen, Humpert Per M, Isermann Berend, Chavakis Triantafyllos, Tafel Jörg, Nosikov Valery V, Hamann Andreas, Nawroth Peter, Bierhaus Angelika

Abstract excerpt

OBJECTIVE: To establish whether single nucleotide polymorphisms (Asp299Gly and Thr399Ile) of the toll-like receptor 4 have an association with late diabetic complications. RESEARCH DESIGN AND METHODS: The study was conducted in 246 type 1 and 530 type 2 diabetic patients. The alleles of both polymorphisms were detected using PCR and subsequent cleavage by NcoI and HinfI restriction endonucleases. RESULTS: No...

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Identifiers

PMID: 14693986
DOI: 10.2337/diacare.27.1.179

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.PMID 14693986Read ↗

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