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Article

Ethnic variation of thiopurine S-methyltransferase activity: a large, prospective population study.

Pharmacogenomics - 1 Mar 2008

Cooper Sheldon C, Ford Loretta T, Berg Jonathan D, Lewis Matthew J V

Abstract excerpt

UNLABELLED: The use of azathioprine (and its metabolite mercaptopurine) is limited by toxicity, especially myelosuppression, which is related to activity of the enzyme thiopurine S-methyltransferase (TPMT). TPMT activity varies between individuals and is considered deficient in one in 300 cases. AIMS & METHODS: We identified TPMT activity within an ethnically diverse population of patients attending an inner-city...

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Source

Identifiers

PMID: 18303966
DOI: 10.2217/14622416.9.3.303

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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