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Article

Thiopurine S-methyltransferase activity in Nigerians: phenotypes and activity reference values.

BMC research notes - 14 Feb 2018

Adehin Ayorinde, Bolaji Oluseye O

Abstract excerpt

OBJECTIVES: This study assessed the activity of thiopurine S-methyltransferase (TPMT) in Nigerians with a view to providing data on susceptibility to thiopurine toxicity, and as well generate reference activity values for clinical use. RESULTS: TPMT activity, expressed as the amount of 6MMP in ng/mL after 1 h incubation at 37 °C per haemoglobin (U/g Hb), varied between 2.34 and 63.50 U/g Hb in the study...

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Source

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Identifiers

PMID: 29444714
DOI: 10.1186/s13104-018-3237-5
PMCID: PMC5813413

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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