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Article

Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.

Clinical pharmacology and therapeutics - 1 Mar 2011

Relling M V, Gardner E E, Sandborn W J, Schmiegelow K, Pui C-H, Yee S W, Stein C M, Carrillo M, Evans W E, Klein T E

Abstract excerpt

Thiopurine methyltransferase (TPMT) activity exhibits monogenic co-dominant inheritance, with ethnic differences in the frequency of occurrence of variant alleles. With conventional thiopurine doses, homozygous TPMT-deficient patients (~1 in 178 to 1 in 3,736 individuals with two nonfunctional TPMT alleles) experience severe myelosuppression, 30-60% of individuals who are heterozygotes (~3-14% of the population)...

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Source

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Identifiers

PMID: 21270794
DOI: 10.1038/clpt.2010.320
PMCID: PMC3098761

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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