Article
Effects of histamine on functional maturation of dendritic cells.
Immunobiology - 1 Jan 2003
Pavlinkova Gabriela, Yanagawa Yoshiki, Kikuchi Kazuhiro, Iwabuchi Kazuya, Onoé Kazunori
Abstract excerpt
There is increasing evidence that histamine affects dendritic cell (DC) activation, maturation, and preference for Th1/Th2 differentiation. In this paper we report that histamine affects interleukin (IL)-12 and IL-6 production in an immature DC (iDC) line derived from murine spleen. Histamine treatment of iDC significantly increased the IL-12 p40 mRNA and protein levels compared to histamine untreated iDC. In the...
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