Article
Differential regulation of epidermal langerhans cell migration by interleukins (IL)-1alpha and IL-1beta during irritant- and allergen-induced cutaneous immune responses.
Toxicology and applied pharmacology - 15 Jul 2002
Cumberbatch Marie, Dearman Rebecca J, Groves Richard W, Antonopoulos Christos, Kimber Ian
Abstract excerpt
Tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-18 are all known to contribute to the regulation of epidermal Langerhans cells (LC) migration and the subsequent accumulation of dendritic cells (DC) in draining lymph nodes following skin sensitization. However, the cytokine signals that control these responses following skin irritation have yet to be defined. We demonstrate that IL-1alpha,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.