Article
CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2004
Pivarcsi Andor, Gombert Michael, Dieu-Nosjean Marie-Caroline, Lauerma Antti, Kubitza Robert, Meller Stephan, Rieker Juliane, Muller Anja, Da Cunha Ludivine, Haahtela Anna, Sonkoly Eniko, Fridman Wolf-Herman, Alenius Harri, Kemeny Lajos, Ruzicka Thomas, Zlotnik Albert, Homey Bernhard
Abstract excerpt
Atopic dermatitis is a chronic inflammatory skin disease with a steadily increasing prevalence. Exposure to allergens or bacterial superantigens triggers T and dendritic cell (DC) recruitment and induces atopic skin inflammation. In this study, we report that among all known chemokines CCL18/DC-CK1/PARC represents the most highly expressed ligand in atopic dermatitis. Moreover, CCL18 expression is associated with...
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