Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus.

The Journal of biological chemistry - 25 Apr 2008

Nagao Kaori, Taniyama Yoshiaki, Kietzmann Thomas, Doi Takefumi, Komuro Issei, Morishita Ryuichi

Abstract excerpt

HIF-1alpha is originally identified as a transcription factor that activates gene expression in response to hypoxia. In metazoans, HIF-1alpha functions as a master regulator of oxygen homeostasis and regulates adaptive responses to change in oxygen tension during embryogenesis, tissue ischemia, and tumorigenesis. Because Hif-1alpha-deficient mice exhibit a number of developmental defects, the precise role of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heart
Share to Homeobox Protein Nkx-2.5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocytes, Cardiac

Share to Oligonucleotides

Share to Oxygen

Share to Troponin I

Share to Xenopus laevis

Share to Xenopus Proteins

Source

Identifiers

PMID: 18303027
DOI: 10.1074/jbc.M702563200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus.PMID 18303027Read ↗

The transcription factor Foxc1a in zebrafish directly regulates expression of nkx2.5, encoding a transcriptional regulator of cardiac progenitor cellsSemantic proximity Read ↗

Nkx2.5: a crucial regulator of cardiac development, regeneration and diseasesSemantic proximity Read ↗

NKX2-5 Regulates the Expression of β-Catenin and GATA4 in Ventricular MyocytesSemantic proximity Read ↗

Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.Semantic proximity Read ↗

Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.Semantic proximity Read ↗

Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development.Semantic proximity Read ↗

Gene-environment interaction impacts on heart development and embryo survivalSemantic proximity Read ↗

WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1.Semantic proximity Read ↗

An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood.Semantic proximity Read ↗

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.Semantic proximity Read ↗

Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases.Semantic proximity Read ↗

Fosl1 is vital to heart regeneration upon apex resection in adult Xenopus tropicalisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.