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Article

An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood.

Developmental biology - 1 Apr 2015

George Vanessa, Colombo Sophie, Targoff Kimara L

Abstract excerpt

Temporally controlled mechanisms that define the unique features of ventricular and atrial cardiomyocyte identities are essential for the construction of a coordinated, morphologically intact heart. We have previously demonstrated an important role for nkx genes in maintaining ventricular identity, however, the specific timing of nkx2.5 function in distinct cardiomyocyte populations has yet to be elucidated....

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Identifiers

PMID: 25536398
DOI: 10.1016/j.ydbio.2014.12.019
PMCID: PMC4361364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood.PMID 25536398Read ↗

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