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Article

An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood.

Developmental biology - 1 Apr 2015

George Vanessa, Colombo Sophie, Targoff Kimara L

Abstract excerpt

Temporally controlled mechanisms that define the unique features of ventricular and atrial cardiomyocyte identities are essential for the construction of a coordinated, morphologically intact heart. We have previously demonstrated an important role for nkx genes in maintaining ventricular identit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeobox Protein Nkx-2.5

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Identifiers

PMID: 25536398
DOI: 10.1016/j.ydbio.2014.12.019
PMCID: PMC4361364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25536398-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood.PMID 25536398Read ↗

Nkx genes are essential for maintenance of ventricular identity.Semantic proximity Read ↗

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A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels.Semantic proximity Read ↗

Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.Semantic proximity Read ↗

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Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2‐5 expressionSemantic proximity Read ↗

Activation of Nkx2.5 transcriptional program is required for adult myocardial repairSemantic proximity Read ↗

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