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Article

Analysis of the regulatory and structural defects of troponin C central helix mutants.

Biochemistry - 23 Jul 1991

Dobrowolski Z, Xu G Q, Chen W, Hitchcock-DeGregori S E

Abstract excerpt

Five deletion mutants of the D/E linker region of the troponin C central helix were tested for conformational and functional differences from wild-type troponin C. The mutants were in the region 87KEDAKGKSEEE97: dEDA, dKG, dKGK, dKEDAKGK, and dSEEE, designed to change the length of the central helix and the orientation of the Ca(2+)-binding domains relative to each other [Dobrowolski, Z., Xu, G.-Q., &...

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Identifiers

PMID: 1830216
DOI: 10.1021/bi00243a008

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