Analysis of the regulatory and structural defects of troponin C central helix mutants.

doi:10.1021/bi00243a008

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Article

Analysis of the regulatory and structural defects of troponin C central helix mutants.

Biochemistry - 23 Jul 1991

Dobrowolski Z, Xu G Q, Chen W, Hitchcock-DeGregori S E

Abstract excerpt

Five deletion mutants of the D/E linker region of the troponin C central helix were tested for conformational and functional differences from wild-type troponin C. The mutants were in the region 87KEDAKGKSEEE97: dEDA, dKG, dKGK, dKEDAKGK, and dSEEE, designed to change the length of the central he...

Topics

Amino Acid Sequence
Calcium
Circular Dichroism
Cloning, Molecular
Electrophoresis, Polyacrylamide Gel
Escherichia coli
Hot Temperature
Molecular Sequence Data
Mutation
Myosins
Protein Conformation
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
Troponin
Troponin C
Troponin I

Source

Open in PubMed

Identifiers

PMID: 1830216
DOI: 10.1021/bi00243a008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1830216-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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