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Article

Structural kinetics of cardiac troponin C mutants linked to familial hypertrophic and dilated cardiomyopathy in troponin complexes.

The Journal of biological chemistry - 8 Feb 2008

Dong Wen-Ji, Xing Jun, Ouyang Yexin, An Jianli, Cheung Herbert C

Abstract excerpt

The key events in regulating cardiac muscle contraction involve Ca(2+) binding to and release from cTnC (troponin C) and structural changes in cTnC and other thin filament proteins triggered by Ca(2+) movement. Single mutations L29Q and G159D in human cTnC have been reported to associate with familial hypertrophic and dilated cardiomyopathy, respectively. We have examined the effects of these individual mutations...

Topics

Actomyosin
Animals
Calcium
Cardiomyopathy, Dilated
Chickens
Cyclic AMP-Dependent Protein Kinases
Fluorescence Resonance Energy Transfer
Hypertrophy
Kinetics
Mutation
Myocardium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Protein Structure, Tertiary

Signal Transduction

Troponin C

Source

Identifiers

PMID: 18063575
DOI: 10.1074/jbc.M703822200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Structural kinetics of cardiac troponin C mutants linked to familial hypertrophic and dilated cardiomyopathy in troponin complexes.PMID 18063575Read ↗

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