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Article

Modified calcium-dependent regulatory function of troponin C central helix mutants.

The Journal of biological chemistry - 25 Mar 1991

Dobrowolski Z, Xu G Q, Hitchcock-DeGregori S E

Abstract excerpt

Mutations have been made in the exposed region of the avian troponin C central helix, the D/E linker, which change its length and the orientation of the Ca2(+)-binding domains relative to each other. The region 87Glu-Asp-Ala-Lys-Gly-Lys-Ser-Glu-Glu-Glu97 has been altered in five deletion (d) mutants: dEDA, dKG, dKGK, dSEEE, and dKEDAKGK. The recombinant troponin Cs were expressed in Escherichia coli, purified,...

Topics

Amino Acid Sequence
Base Sequence
Calcium
Chromatography, High Pressure Liquid
Escherichia coli
Molecular Sequence Data
Mutation
Myosins
Osmolar Concentration
Phenotype
Spectrometry, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Troponin

Troponin C

Source

Identifiers

PMID: 1826002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1826002-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Modified calcium-dependent regulatory function of troponin C central helix mutants.PMID 1826002Read ↗

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