Article
Higher cross-subtype IFN-γ ELISpot responses to Gag and Nef peptides in Brazilian HIV-1 subtype B- and F1- than in C-infected subjects.
Vaccine - 4 Feb 2013
Côrtes Fernanda Heloise, Bello Gonzalo, Vorsatz Carla, Pilotto José Henrique, Guimarães Monick Lindenmeyer, Grinsztejn Beatriz, Veloso Valdiléa Gonçalves, Pinto Aguinaldo Roberto, Morgado Mariza Gonçalves
Abstract excerpt
HIV-1 diversity has been considered a huge challenge for the HIV-1 vaccine development. To overcome it, immunogens based on centralized sequences, as consensus, have been tested. In Brazil, the co-circulation of three subtypes offers a suitable scenario to test T cell cross-subtype responses to consensus sequences. Furthermore, we included peptides based on closest viral isolates (CVI) from each subtype analyzed...
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