Article
A novel polymorphism of the CYP4A11 gene is associated with coronary artery disease.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 1 Jan 2000
Fu Zhenyan, Ma Yitong, Xie Xiang, Huang Ding, Yang Hong, Nakayama Tomohiro, Sato Naoyuki
Abstract excerpt
BACKGROUND: CYP4A11 (cytochrome P450, family 4, subfamily A, polypeptide 11) converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the modulation of cardiovascular homeostasis. The aim of the present study was to assess the association between the human CYP4A11 gene and coronary artery disease (CAD). METHODS: A total of 361 patients with CAD and 315 controls were...
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