Article
Haplotype-based case-control study of the human CYP4F2 gene and essential hypertension in Japanese subjects.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Sept 2008
Fu Zhenyan, Nakayama Tomohiro, Sato Naoyuki, Izumi Yoichi, Kasamaki Yuji, Shindo Atsushi, Ohta Masakatsu, Soma Masayoshi, Aoi Noriko, Sato Mikano, Matsumoto Koichi, Ozawa Yukio, Ma Yitong
Abstract excerpt
CYP4F2 acts primarily as an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite involved in the regulation of blood pressure in humans. The aim of the present study was to assess the association between the human CYP4F2 gene and essential hypertension (EH) using a haplotype-based case-control study that included separate analysis of the two gender groups. The 249 EH...
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