Article
Influence of cytokine gene polymorphisms on IgA nephropathy.
Renal failure - 1 Jan 2008
Bantis Christos, Heering Peter, Aker Sendogan, Kuhr Nicola, Grabensee Bernd, Ivens Katrin
Abstract excerpt
Aims. Recently, polymorphisms of cytokine genes have been associated with altered gene expression and modified cytokine production. We evaluated the impact of TGF-beta1 gene Arg(25)-->Pro, TNFalpha gene G-308A and IL-6 gene G-174C polymorphisms on the clinical manifestations of IgA nephropathy. Patients and methods. The clinical course of 127 patients with biopsy-proven IgA nephropathy followed up for 6.6 +/- 6.0...
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