Article
No association of the -2518 MCP-1 A/G promoter polymorphism with incidence and clinical course of IgA nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2004
Steinmetz Oliver M, Panzer Ulf, Harendza Sigrid, Mertens Peter R, Ostendorf Tammo, Floege Jürgen, Helmchen Udo, Stahl Rolf A K
Abstract excerpt
BACKGROUND: The clinical course of IgA nephropathy is highly variable, ranging from complete remission to progression with end-stage renal disease. Although the mechanisms involved in disease progression are not characterized in detail, loss of renal function is positively correlated with mononuclear cell infiltration. In general, chemokines play an important role in the directional recruitment of inflammatory...
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