Article
Influence of cytokine gene polymorphisms on focal segmental glomerulosclerosis.
American journal of nephrology - 1 Jan 2000
Bantis Christos, Heering Peter J, Luther Yvonne, Aker Sendogan, Kuhr Nicola, Grabensee Bernd, Ivens Katrin
Abstract excerpt
BACKGROUND: Recently, polymorphisms of cytokine genes have been associated with modified gene expression and increased cytokine production. We evaluated the influence of TGF-beta(1) gene Arg(25)-->Pro, TNF alpha gene G-308A and IL-6 gene G-174C polymorphisms on the clinical manifestations of focal segmental glomerulosclerosis (FSGS). METHODS: The clinical course of 71 patients with biopsy-proven primary FSGS...
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