Article
Predictive value of cytokine gene polymorphisms for the development of end-stage renal disease.
Journal of nephrology - 1 Jan 2000
Babel Nina, Gabdrakhmanova Lelia, Hammer Markus H, Schoenemann Constanze, Skrypnikov Volodimir, Poliak Nina, Volk Hans-Dieter, Reinke Petra
Abstract excerpt
BACKGROUND: Cytokines play a crucial role in different immunopathological conditions. Cytokine secretion is reported to be determined by polymorphisms in the cytokine genes. Since TNF-alfa and IL-10 are involved in regulation of inflammation, and TGF-beta 1 can induce fibrosis and renal insuffici...
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