Article
Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke.
Neurology - 28 Dec 2004
Kölsch H, Linnebank M, Lütjohann D, Jessen F, Wüllner U, Harbrecht U, Thelen K M, Kreis M, Hentschel F, Schulz A, von Bergmann K, Maier W, Heun R
Abstract excerpt
BACKGROUND: Glutathione S-transferase omega-1 (GSTO1) protects from oxidative stress, a risk factor for Alzheimer disease (AD), vascular dementia (VaD), and stroke. Polymorphisms in GSTO1 might influence the function of the protein and thus the risk of AD, VaD, and stroke. METHODS: The GSTO1 gene was screened for variations. The effect of the detected polymorphisms on the risk of AD, VaD, and stroke was...
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