Article
rs2070424 of the SOD1 gene is associated with risk of Alzheimer's disease.
Neurologia i neurochirurgia polska - 1 Jan 2014
Spisak Karolina, Klimkowicz-Mrowiec Aleksanda, Pera Joanna, Dziedzic Tomasz, Aleksandra Golenia, Slowik Agnieszka
Abstract excerpt
OBJECTIVE: Oxidative stress plays an important role in Alzheimer's disease (AD) etiopathogenesis. There were several studies that showed impaired antioxidant defense system (ADS) enzymes expression or activity in AD patients. There are only few studies evaluating the importance of ADS gene single nucleotide polymorphisms (SNPs) as risk factors of AD. We evaluated association between chosen SNPs of the enzymes of...
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