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Article

Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain.

Neurobiology of disease - 1 Feb 2000

Ramassamy C, Averill D, Beffert U, Theroux L, Lussier-Cacan S, Cohn J S, Christen Y, Schoofs A, Davignon J, Poirier J

Abstract excerpt

The epsilon4 allele of the apolipoprotein E gene (APOE) is associated with sporadic and familial late-onset Alzheimer's disease (AD). Oxidative stress is believed to play an important role in neuronal dysfunction and cell death in AD. We now provide evidence that in the hippocampus of AD, the level of thiobarbituric acid-reactive substances (TBARS) and the APOE genotype are linked. Within AD cases, the levels of...

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Source

Identifiers

PMID: 10671320
DOI: 10.1006/nbdi.1999.0273

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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