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Article

GSTO1*E155del polymorphism associated with increased risk for late-onset Alzheimer's disease: association hypothesis for an uncommon genetic variant.

Neuroscience letters - 11 Jan 2012

Piacentini Sara, Polimanti Renato, Squitti Rosanna, Mariani Stefania, Migliore Simone, Vernieri Fabrizio, Rossini Paolo Maria, Manfellotto Dario, Fuciarelli Maria

Abstract excerpt

Glutathione S-transferases are multifunctional enzymes involved in cellular detoxification. A genetic linkage was found between Alzheimer's Disease (AD) and the chromosome 10q, where the GSTO1 and GSTO2 genes are located, leading to the hypothesis that GST Omega class (GSTO) genes may be an AD risk factor. Since it is still controversial, we decided to explore GSTO polymorphisms in Italian cohorts. We analyzed...

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Source

Identifiers

PMID: 22100662
DOI: 10.1016/j.neulet.2011.11.005

Genes

GSTO1
GSTO2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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