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Article

Accommodation of Ca(II) ions for catalytic activity by a group I ribozyme.

Journal of inorganic biochemistry - 1 Jul 2008

Cernak Paul, Madix Rowan A, Kuo Louis Y, Lehman Niles

Abstract excerpt

The wildtype Tetrahymena ribozyme cannot catalyze detectable levels of phosphotransfer activity in vitro on an exogenous RNA substrate oligonucleotide when calcium(II) is supplied as the only available divalent ion. Nevertheless, low-error mutants of this ribozyme have been acquired through directed evolution that do have activity in 10mM CaCl(2). The mechanisms for such Ca(II) accommodation are not known. Here,...

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Identifiers

PMID: 18295895
DOI: 10.1016/j.jinorgbio.2008.01.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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