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Article

Roles of Saccharomyces cerevisiae DNA polymerases Poleta and Polzeta in response to irradiation by simulated sunlight.

Nucleic acids research - 1 Aug 2003

Kozmin Stanislav G, Pavlov Youri I, Kunkel Thomas A, Sage Evelyne

Abstract excerpt

Sunlight causes lesions in DNA that if unrepaired and inaccurately replicated by DNA polymerases yield mutations that result in skin cancer in humans. Two enzymes involved in translesion synthesis (TLS) of UV-induced photolesions are DNA polymerase eta (Poleta) and polymerase zeta (Polzeta), encoded by the RAD30A and REV3 genes, respectively. Previous studies have investigated the TLS roles of these polymerases...

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Identifiers

PMID: 12888515
DOI: 10.1093/nar/gkg489
PMCID: PMC169879

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