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Article

Molecular evidence of the independent origin of multiple Wilms tumors in a case of WAGR syndrome.

Pediatric blood & cancer - 1 Sept 2008

Uccini Stefania, Perotti Daniela, Colarossi Cristina, Stoppacciaro Antonella, Sardella Michele, Mannarino Olga, Collini Paola, Casieri Paola, Cozzi Denis, Amoroso Loredana, Spreafico Filippo, Radice Paolo, Dominici Carlo

Abstract excerpt

BACKGROUND: This study investigated the genetic events leading to tumorigenesis in a patient affected with WAGR syndrome who developed multiple distinct Wilms tumors (WTs). PROCEDURE AND RESULTS: At 1 year of age, the child developed two synchronous bilateral WTs that were resected by partial nephrectomy. Histologically, these tumors were fetal rhabdomyomatous nephroblastomas. Immunohistochemical study revealed...

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PMID: 18293378
DOI: 10.1002/pbc.21507

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CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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