Article
Clinical relevance of mutations in the Wilms tumor suppressor 1 gene WT1 and the cadherin-associated protein beta1 gene CTNNB1 for patients with Wilms tumors: results of long-term surveillance of 71 patients from International Society of Pediatric Oncology Study 9/Society for Pediatric Oncology.
Cancer - 1 Sept 2008
Royer-Pokora Brigitte, Weirich Angela, Schumacher Valerie, Uschkereit Constanze, Beier Manfred, Leuschner Ivo, Graf Norbert, Autschbach Frank, Schneider Dominique, von Harrach Melissa
Abstract excerpt
BACKGROUND: Mutations in the Wilms tumor (WT) suppressor 1 gene (WT1) and the cadherin-associated protein beta1 gene (CTNNB1) are found predominantly in stromal type WT, defining a genetic subgroup. The clinical relevance of these mutations remains to be determined. METHODS: A long-term follow-up study was performed for 71 patients (International Society of Pediatric Oncology Study 9/Society for Pediatric...
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