Article
Genetic variation in RNASEL and risk for prostate cancer in a population-based case-control study.
The Prostate - 1 Oct 2011
Fesinmeyer Megan D, Kwon Erika M, Fu Rong, Ostrander Elaine A, Stanford Janet L
Abstract excerpt
BACKGROUND: Linkage studies have implicated chromosome 1q24 as a putative locus for hereditary prostate cancer. The RNASEL gene maps to 1q24 and has been associated with prostate cancer risk in multiple family-based linkage studies. The RNASEL gene product combats viral infection by degrading viral RNA and inducing apoptosis of infected cells. Few studies have evaluated the role of RNASEL variants in unselected...
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