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Article

RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases.

Nature genetics - 1 Dec 2002

Casey Graham, Neville Phillippa J, Plummer Sarah J, Xiang Ying, Krumroy Lisa M, Klein Eric A, Catalona William J, Nupponen Nina, Carpten John D, Trent Jeffrey M, Silverman Robert H, Witte John S

Abstract excerpt

RNASEL (encoding ribonuclease L) has recently been proposed as a candidate for the hereditary prostate cancer (HPC1) gene. We determined that the RNASEL variant Arg462Gln has three times less enzymatic activity than the wildtype and is significantly associated with prostate cancer risk (P = 0.007). At least one copy of the mutated allele that causes this substitution is carried by nearly 60% of the men in our...

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Identifiers

PMID: 12415269
DOI: 10.1038/ng1021

Genes

RNASEL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases.PMID 12415269Read ↗

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RNASEL Arg462Gln polymorphism and prostate cancer in PLCO.Semantic proximity Read ↗

Germline Alterations of the RNASEL Gene, a Candidate HPC1 Gene at 1q25, in Patients and Families with Prostate CancerSemantic proximity Read ↗

Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL.Semantic proximity Read ↗

Evidence from 40 Studies that 2 Common Single-Nucleotide Polymorphisms (SNPs) of RNASEL Gene Affect Prostate Cancer Susceptibility: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-Compliant Meta-Analysis.Semantic proximity Read ↗

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