Article
Association of hereditary prostate cancer gene polymorphic variants with sporadic aggressive prostate carcinoma.
The Prostate - 1 Jan 2006
Noonan-Wheeler Ferrin C, Wu William, Roehl Kimberly A, Klim Aleksandra, Haugen John, Suarez Brian K, Kibel Adam S
Abstract excerpt
BACKGROUND: ELAC2, MSR1, and RNASEL are candidate genes for hereditary prostate carcinoma (HPC). While, studies have demonstrated that single nucleotide polymorphisms (SNPs) in these genes are associated with sporadic disease as well as HPC, these results are often not replicated in follow-up studies. Given that the majority of patients studied had localized disease and up to 50% of localized prostate cancer is...
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