Article
Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2004
Wiklund Fredrik, Jonsson Björn-Anders, Brookes Anthony J, Strömqvist Linda, Adolfsson Jan, Emanuelsson Monica, Adami Hans-Olov, Augustsson-Bälter Katarina, Grönberg Henrik
Abstract excerpt
PURPOSE: The RNASEL gene has been proposed as a candidate gene for the HPC1 locus through a positional cloning and candidate gene approach. Cosegregation between the truncating mutation E265X and disease in a hereditary prostate cancer (HPC) family and association between prostate cancer risk and the common missense variant R462Q has been reported. To additionally evaluate the possible role of RNASEL in...
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