Article
Pivotal role for aspartate-80 in the regulation of dopamine D2 receptor affinity for drugs and inhibition of adenylyl cyclase.
Molecular pharmacology - 1 Jun 1991
Neve K A, Cox B A, Henningsen R A, Spanoyannis A, Neve R L
Abstract excerpt
An aspartate residue corresponding to aspartate-80 of dopamine D2 receptors is strictly conserved among receptors that couple to guanine nucleotide-binding proteins. Mutation of this residue alters the function of several classes of neurotransmitter receptors. Dopamine D2 receptors couple to the guanine nucleotide-binding protein Gi to inhibit adenylyl cyclase (ATP-pyrophosphate-lyase, cyclizing; EC 4.6.1.1)....
Topics
- Adenylyl Cyclase Inhibitors
- Amino Acid Sequence
- Aspartic Acid
- Benzamides
- Ethylmaleimide
- Hydrogen-Ion Concentration
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Pyrrolidines
- Radioligand Assay