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Article

Receptor conformations involved in dopamine D(2L) receptor functional selectivity induced by selected transmembrane-5 serine mutations.

Molecular pharmacology - 1 Jun 2012

Fowler J Corey, Bhattacharya Supriyo, Urban Jonathan D, Vaidehi Nagarajan, Mailman Richard B

Abstract excerpt

Although functional selectivity is now widely accepted, the molecular basis is poorly understood. We have studied how aspects of transmembrane region 5 (TM5) of the dopamine D(2L) receptor interacts with three rationally selected rigid ligands (dihydrexidine, dinapsoline, and dinoxyline) and the reference compounds dopamine and quinpirole. As was expected from homology modeling, mutation of three TM5 serine...

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PMID: 22416052
DOI: 10.1124/mol.111.075457
PMCID: PMC3362898

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Source receipt: pubmed, retrieved 7 Sept 2026.

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