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Article

Importance of a N-terminal aspartate in the internalization of the neuropeptide Y Y2 receptor.

European journal of pharmacology - 10 Oct 2008

Parker Steven L, Parker Michael S, Wong Ying Y, Sah Renu, Balasubramaniam Ambikaipakan, Sallee Floyd

Abstract excerpt

With human neuropeptide Y Y2 receptor expressed in the Chinese hamster ovary (CHO) cells, the Asp35Ala mutation, and especially the change of Pro34Asp35 to Ala34Ala35, decrease the compartmentalization and strongly accelerate internalization of the receptor. These changes are not associated with alterations in agonist affinity, G-protein interaction, dimerization, or level of expression of the mutated receptors...

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Identifiers

PMID: 18700141
DOI: 10.1016/j.ejphar.2008.07.038
PMCID: PMC2579264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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