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Article

Pivotal role of an aspartate residue in sodium sensitivity and coupling to G proteins of neurotensin receptors.

Molecular pharmacology - 1 Feb 1999

Martin S, Botto J M, Vincent J P, Mazella J

Abstract excerpt

The highly conserved aspartate residue in the second transmembrane domain of G protein-coupled receptors is present in position 113 in the type 1 neurotensin receptor (NTR1) but is replaced by an Ala residue in position 79 in the type 2 neurotensin receptor (NTR2). NTR1 couples to Galphaq to stimulate phospholipase C and its binding affinity for neurotensin is decreased by sodium ions and GTP analogs. By...

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Identifiers

PMID: 9927610
DOI: 10.1124/mol.55.2.210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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