Article
Distinct agonist- and antagonist-binding sites on the glycine receptor.
Neuron - 1 Sept 1992
Vandenberg R J, Handford C A, Schofield P R
Abstract excerpt
The distinction between receptor-binding sites for agonists and antagonists underpins the pharmacological differences between these two classes of ligands. In the glycine receptor, antagonist (strychnine) binding requires an interaction with residues Lys-200 and Tyr-202. We now demonstrate that t...
Topics
- Alanine
- Amino Acid Sequence
- Binding Sites
- Binding, Competitive
- Glycine
- Humans
- Ligands
- Molecular Sequence Data
- Mutation
- Receptors, Glycine
- Receptors, Neurotransmitter
- Strychnine
- Taurine