Article
Site-directed mutagenesis of the human dopamine D2 receptor.
European journal of pharmacology - 1 Oct 1992
Mansour A, Meng F, Meador-Woodruff J H, Taylor L P, Civelli O, Akil H
Abstract excerpt
Based on amino acid sequence and computer modeling, two conflicting three-dimensional models of the dopamine D2 receptor have been proposed. One model (Dahl et al., 1991, Proc. Natl. Acad. Sci. USA 88, 8111) suggests that dopamine interacts with aspartate 80 of transmembrane (TM) 2 and asparagine...
Topics
- Amino Acid Sequence
- Blotting, Northern
- Dopamine Agents
- Dopamine D2 Receptor Antagonists
- Humans
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Raclopride
- Radioligand Assay
- Receptors, Dopamine D2
- Salicylamides
- Sequence Alignment
- Transfection