Article
Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors.
Journal of neurochemistry - 1 Aug 1992
Cox B A, Henningsen R A, Spanoyannis A, Neve R L, Neve K A
Abstract excerpt
Four dopamine D2 receptor mutants were constructed, in each of which an alanine residue was substituted for one of four conserved serine residues, i.e., Ser-193, Ser-194, Ser-197, and Ser-391. Wild-type and mutant receptors were expressed transiently in COS-7 cells and stably in C6 glioma cells f...
Topics
- Adenylyl Cyclase Inhibitors
- Alanine
- Animals
- Base Sequence
- Benzamides
- Cell Line
- Glioma
- Immunoblotting
- Iodine Radioisotopes
- Ligands
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Pyrrolidines
- RNA, Messenger
- Radioligand Assay
- Receptors, Adrenergic, beta
- Receptors, Dopamine