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Article

Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression.

Archives of general psychiatry - 1 Feb 2004

Frodl Thomas, Meisenzahl Eva M, Zill Peter, Baghai Thomas, Rujescu Dan, Leinsinger Gerda, Bottlender Ronald, Schüle Cornelius, Zwanzger Peter, Engel Rolf R, Rupprecht Rainer, Bondy Brigitta, Reiser Maximilian, Möller Hans-Jürgen

Abstract excerpt

BACKGROUND: Substantial evidence supports a role for dysfunction of the serotonin transporter in the pathogenesis of major depression. Several studies have found reciprocal interactions between the serotonergic system and both brain-derived neurotrophic factor and glutamate, which are known to modulate or affect hippocampal morphologic characteristics. OBJECTIVE: To examine the influence of a polymorphism...

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PMID: 14757594
DOI: 10.1001/archpsyc.61.2.177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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