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Article

Familial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I*.

PloS one - 1 Jan 2013

Li Alison Y, Stevens Charles M, Liang Bo, Rayani Kaveh, Little Sean, Davis Jonathan, Tibbits Glen F

Abstract excerpt

The Ca(2+) binding properties of the FHC-associated cardiac troponin C (cTnC) mutation L29Q were examined in isolated cTnC, troponin complexes, reconstituted thin filament preparations, and skinned cardiomyocytes. While higher Ca(2+) binding affinity was apparent for the L29Q mutant in isolated cTnC, this phenomenon was not observed in the cTn complex. At the level of the thin filament in the presence of...

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Identifiers

PMID: 24260207
DOI: 10.1371/journal.pone.0079363
PMCID: PMC3832503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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