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Article

The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q.

Journal of molecular and cellular cardiology - 1 Oct 2015

Robertson Ian M, Sevrieva Ivanka, Li Monica X, Irving Malcolm, Sun Yin-Biao, Sykes Brian D

Abstract excerpt

Familial hypertrophic cardiomyopathy (FHC) is characterized by severe abnormal cardiac muscle growth. The traditional view of disease progression in FHC is that an increase in the Ca(2+)-sensitivity of cardiac muscle contraction ultimately leads to pathogenic myocardial remodeling, though recent studies suggest this may be an oversimplification. For example, FHC may be developed through altered signaling that...

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Source

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Identifiers

PMID: 26341255
DOI: 10.1016/j.yjmcc.2015.08.017
PMCID: PMC4640586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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