Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.

doi:10.1074/jbc.M110.112326

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Article

Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.

The Journal of biological chemistry - 3 Sept 2010

Parvatiyar Michelle S, Pinto Jose Renato, Liang Jingsheng, Potter James D

Abstract excerpt

Cardiac diseases associated with mutations in troponin subunits include hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM). Altered calcium handling in these diseases is evidenced by changes in the Ca(2+) sensitivity of contraction. Mutations in the Ca(2+) sensor, troponin C (TnC), were generated to increase/decrease the Ca(2+) sensitivity of cardiac skinned...

Topics

Actomyosin
Adenosine Triphosphatases
Animals
Calcium
Cardiomyopathies
Enzyme Activation
Humans
Mice
Models, Molecular
Muscle Fibers, Skeletal
Mutation
Myocardial Contraction
Phenotype
Protein Engineering
Protein Structure, Secondary
Rabbits
Troponin C

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Identifiers

PMID: 20566645
DOI: 10.1074/jbc.M110.112326
PMCID: PMC2934646

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